Synergistic activity of weak organic acids against uropathogens

SummaryBackground Urinary tract infections (UTIs) are among the most common hospital-acquired infections, with an estimated 75% of UTIs caused by urinary catheters. In addition to significant healthcare costs and patient morbidity, escalating antimicrobial resistance reported uropathogens make investigation efficacious new strategies urgent importance. Aim To examine antibacterial activity a suite weak organic acids (WOAs) (citric acid, malic propionic mandelic lactic benzoic pyruvic acid hippuric acid), alone in combination, against nosocomial (Proteus mirabilis, Staphylococcus aureus, Escherichia coli Pseudomonas aeruginosa). Methods Minimum inhibitory concentration (MIC), minimum bactericidal (MBC), biofilm eradication (MBEC), fractional index (FICI) values kinetics WOAs were determined microdilution time-kill assays. Findings All tested displayed activities their planktonic modes growth when used individually. Moreover, combination synergistic P. S. aureus E. coli, reductions MIC up 250-fold formation. Conclusion The multi-mechanistic combinations identified herein anticipated play important role treatment prevention catheter-associated UTIs.